Sunday, September 29, 2019

        SUSTAINABLE DEVELOPMENT                                          GOAL 6


 PROGRESS OF GOAL 6 IN 2019
GOAL 6 Ensure availability and sustainable management of water and sanitation for all,Despite progress, billions of people still lack safe water, sanitation and handwashing facilities. Data suggests that achieving universal access to even basic sanitation service by 2030 would require doubling the current annual rate of progress. More efficient use and management of water are critical to addressing the growing demand for water, threats to water security and the increasing frequency and severity of droughts and floods resulting from climate change. As of the time of writing, most countries are unlikely to reach full implementation of integrated water resources management by 2030. 


  • Globally, the proportion of population using safely managed drinking water services increased from 61 to 71 per cent between 2000 and 2015 and remained unchanged in 2017. An additional 19 per cent of the global population used basic drinking water services. This means that 785 million people still lacked even a basic drinking water service. 

  • The global population using safely managed sanitation services increased from 28 per cent in 2000 to 43 per cent in 2015 and to 45 per cent in 2017, with the greatest increases occurring in Latin America and the Caribbean, sub-Saharan Africa and East and South-East Asia. Between 2000 and 2017, the proportion lacking even a basic sanitation service decreased from 44 to 27 per cent, yet 701 million people still practiced open defecation in 2017. E/2019/68 19-07404 13/39

  •  In 2017, some 60 per cent of people worldwide and only 38 per cent in least developed countries had a basic handwashing facility with soap and water at home, leaving an estimated 3 billion people without basic handwashing facilities at home.

  •  In 2016, one third of all primary schools lacked basic drinking water, sanitation and hygiene services, affecting the education of millions of schoolchildren, but particularly girls managing menstruation, and one in four health-care facilities worldwide lacked basic water services, affecting more than 2 billion people.

  • Approximately one third of countries have medium or high levels of water stress. Almost all countries that have registered high water stress are located in North Africa and West Asia or in Central and South Asia, and these levels indicate serious water difficulties in the supply of freshwater, at least during parts of the year. 

  • Of 172 countries, 80 per cent have medium-low implementation or better of integrated water resources management. However, 60 per cent of countries are unlikely to reach the target of full implementation by 2030.
  • A significant effort is needed to ensure that cooperation is operational in all transboundary basins. According to data from 67 of 153 countries that share transboundary waters, the average percentage of national transboundary basins covered by an operational arrangement was 59 per cent in the period 2017–2018, with only 17 countries reporting that all their transboundary basins were covered by such arrangements. 

  • Following several years of steady increases and after reaching $9 billion in 2016, ODA disbursements to the water sector declined by 2 per cent from 2016 to 2017. However, ODA commitments to the water sector jumped by 36 per cent between 2016 and 2017, indicating a renewed focus by donors on the sector.
 Source: Report of the Secretary-General, Special edition: progress towards the Sustainable

Thursday, September 19, 2019

               HEALTH CARE PRESENTS 6                                     INNOVATIONS





Today's  Medical News,Healthcare Exhibition and Conference. Delegates presented us with technology, both new and old, destined to push healthcare forward. Future Healthcare is an annual event that takes place in London in the United Kingdom. It is a showcase of international innovation in the healthcare space. This year, over 350 brands attended. We spent much of our time listening to short introductions to new products in the Health Innovators Theatre. They all had the potential to change the way that healthcare professionals deliver and monitor healthcare. As ever, data and the way experts manipulate them featured heavily. As one presenter asked, "Data [are] the answer, what is the question?" However, there were also companies attempting to reinvent old technologies using a fresh approach. Below is a brief introduction to some of the products that piqued our interest this year.


1. Detecting dementia
early Today, Alzheimer's disease — the most common form of dementia — is one of the leading causes of death in the United States. As the population's average age slowly rises, the number of deaths due to dementia are likely to rise in line. Despite this, catching dementia early remains challenging. Oxford Brain Diagnostics believe that their technology can catch the condition years before symptoms become apparent. Their secret lies in cortical disarray measurement (CDM). In short, this technique enables scientists to gather an "extra level of detail" from existing MRI scans . This allows them to detect changes in the microanatomy of the brain. Dr. Steven Chance — Oxford Brain Diagnostics' CEO — told MNT that "CDM extracts information about the microscopic structure of the brain's gray matter by applying a unique analysis to a standard form of MRI scan." The method reveals the damage to the cerebral cortex even in the early stages of disease because it is sensitive to disruption at the cellular scale." Dr. Steven Chance Alongside the obvious benefits of spotting the signs of dementia earlier, the technology might also assist the pharmaceutical industry: Researchers could quantify how experimental drugs affect the microstructure of the brain. 

2. Blockchain for health
Healthcare has always been about the patient, of course. However, in recent years, there has been an increasing push to involve the patient more deeply. Particularly, there has been discussion around how doctors store our data, who keeps them, and how they are shared. Medicalchain want to change how people access their medical records. By using secure blockchain technology — most famous for its use in cryptocurrency — they have designed a way that patients can view and, when necessary, share their data with clinicians. Medicalchain have outlined their product in a white paper: "Medicalchain enables the user to give healthcare professionals access to their personal health data. Medicalchain then records interactions with [these] data in an auditable, transparent, and secure way on Medicalchain's distributed ledger." This technology, the company believes, would empower the patient. Also, as online consultations become more popular, this technology would help overcome some of their inherent privacy and security issues. The company hope that soon, their services could be open to the public at large.

 3. Mobile cancer screening
In 2018 globally, there were 570,000 new cases of cervical cancer. Around 90 percent of deaths from cervical cancer occur in low- and middle-income societies. Better screening and earlier intervention could significantly reduce the mortalty rate. MobileODT have designed a battery-powered, hand-held colposcope called the EVA System, which can take high-quality images of the cervix. MobileODT worked with the National Cancer Institute to develop a machine learning algorithm, called automatic visual evaluation (AVE), that can produce an accurate diagnosis in minutes. A prospective, multicenter pilot study that scientists conducted in Korea showed that the device is more than 90 percent accurate. Yael Misrahi — head of global partnerships at MobileODT — outlined the product at Future Healthcare. MNT caught up with her after the event, and she explained that one of the primary benefits of this system is that "it is handheld and can be used by a nonexpert healthcare provider." Because the device is based on smartphone technology, it is user-friendly and includes a "remote consultation feature to consult experts either in real-time or during a quality assurance check." [W]ith AVE — the machine learning algorithm for detection of pre-cancer — there is no need for a scrape or a lab and a woman is able to receive a result at the point of care rather than waiting several weeks or months for a result." Yael Misrahi 

4. Upgrading disposable batteries
How batteries work has remained relatively unchanged for decades. BlueThink — without altering the underlying chemistry — have developed a way of making a common type of battery safer and more cost-effective. Manufacturers now widely use button batteries in medical devices, as BlueThink's Javier Eduardo Nadal explained to MNT: "Medical devices are now smarter and more user-friendly than ever before." "This growing trend relies on good design and the use of technologies like LEDs and screens to improve the user experience, as well as connectivity to provide patients, doctors, and healthcare systems with valuable data." "All these innovative devices have one thing in common: They need energy." Button batteries are not without their problems; if a person leaves them on a shelf for a long time, they lose their charge. If they are incinerated — for instance, those of contaminated disposable medical equipment — they explode. They are also harmful to the environment and a significant hazard for children if swallow,they have found a way to mitigate all of the above. Using standard battery technology but with a twist, they have created a flexible battery that a child could safely swallow, that does not explode when incinerated, and that keeps its charge when left on a shelf. Importantly, it is also low-cost and producible in large quantities. Nadal told MNT that "small amount of energy can make a big difference in a medical device, but it must not compromise user experience, safety, or sustainability."


 5. Robots vs. loneliness
Loneliness is a real, increasing issue in the U.S. and globally. In fact, many healthcare professionals now recognize loneliness as a risk factor for a number of medical conditions, including cardiovascular disease. For this reason, we need to address loneliness with urgency. Service Robotics Limited have recently created an innovative solution that aims to bridge this gap. Genie Connect is a friendly looking miniature robot. The designers described it as "a companion robot service that uses a friendly, intuitive, voice-enabled robot to offer connectivity and support [...] older adults." It can carry out commands in a similar way to other popular virtual assistants, but it has a range of bespoke, customizable features. Genie Connect can have a conversation and set up video chats with healthcare professionals and family members. Service Robotics Limited designed it to help stimulate and engage the user's mind. It also reminds the user when to take medication and attend appointments. There is a common concern that robots will take away the jobs of humans; in this case, Genie Connect fills a gap that humans currently leave open.


 6. Breathe more easily? 
Perhaps the most unusual device we saw at Future Healthcare 2019 was called SoeMac. According to its creators, "SoeMac alternative therapy creates energized oxygen, which your body can safely use to help restore itself at night while you sleep." SoeMac is a small, rectangular device that gently whirrs. A user simply switches it on and leaves it by their bed at night. According to the designers, it helps us breathe more easily and sleep better. They say that "it works by drawing air inside and producing a bio-usable form of energized oxygen, known as Singlet Oxygen Energy, or SOE." "This can help your body to carry out essential restorative work while you sleep at night, boosting the effectiveness of your nighttime detoxification and bodily repair functions." It is crucial to note that so far, no clinical trials back up these claims. However, SoeMac's creators are planning studies in the near future. In particular, they hope that it might give relief to people with chronic obstructive pulmonary disease. Overall, Future Healthcare 2019 was a thoroughly interesting event. It is always exciting being party to the cutting edge of medical innovation.

darriussimps017@gmail.com ,,+260971403393

Tuesday, September 17, 2019

                   TODAY'S TECHNOLOGY 

Soccket ball

Jessica O Matthews: the tech entrepreneur making renewable energy available for all"the  Successful entrepreneurs often have an “a-ha” moment, and for Jessica O Matthews, it came at her aunt’s wedding in Nigeria. While guests celebrated, the power went out – typical for a country with unstable electricity service. When venue workers brought in diesel generators, the party resumed, but Jessica worried how unfazed everyone was about the toxic smell. “They’d all gotten used to it,” says Jessica, who was 19 at the time and a student at Harvard University. “And yet I knew a safer, more practical option existed.” Later, when brainstorming with friends, she thought of a renewable energy soccer ball that charges up as users play. Essentially it was an eco-friendly, portable generator that also serves as sports equipment. Three years later, in 2011, the resulting product, Sockket, helped Jessica launch her company, Uncharted Play (U-Play). Kids from all over and even two former US presidents – Barack Obama and Bill Clinton – embraced the ball and, later, a generator jump rope.
Jessica o mathews


                      ABOUT THE PROJECT



sOccket is a soccer ball that generates cheap, clean, off-grid electricity when rolled. The sOccket ball captures the energy from impact that is normally lost to the environment when the soccer ball is kicked, dribbled, or thrown and stores this energy for later use. The project was created by Jessica Lin and three other female Harvard University students—Jessica Matthews, Julia Silverman, and Hemali Thakkar. They were inspired by dance floors that capture the energy of dancers jumping and moving around. The ball uses inductive coil technology--similar to flashlights that power up when shaken. Each 30 minutes of play with the ball generates enough power to light up an LED lamp for 3 hours, so a soccer game could easily provide light for a day. sOccket is producing its second round of prototypes and is working with working with a prototyping team and technical adviser associated with a new idea incubator at Harvard University. sOccket has been successfully piloted in Durban, South Africa. Early prototypes of the ball weigh just five ounces more than a regulation soccer ball, and their designs are getting lighter. sOccket plans to explore constructing the ball from materials local to Africa, as well as ball designs which will be durable in harsh conditions of dust, rain, and heat. sOccket has attracted several development funding grants and is now in the process of developing production and distribution partnerships.





 In what ways is this project unique and creative?

sOccket is a truly creative and fun way to harvest power for use in resource-poor settings where access to electrical grids is limited or nonexistent. 


What is the social value of this project?

In most African countries, 95 percent of the population is living off-grid with no access to electricity. With sOccket, people in developing nations will no longer need to walk 3 hours simply to charge their cell phones. The power will—quite literally—be in their hands. The sOccket ball can be used to light an LED lamp, or charge a cellphone or battery. sOccket will also benefit its users’ health: more than 1 billion people around the world rely on kerosene lamps to light their homes and businesses when the sun goes down. Not only is kerosene expensive, but its flames are dangerous and the smoke poses serious health risks. In fact, respiratory infections account for the largest percentage of childhood deaths in developing nations—more than AIDS, and more than malaria. 

What is the potential of this project to expand and develop?

sOccket hopes to sell a high-end model for purchase in the U.S. and Europe using a “buy one-give one” offer to subsidize the cost of distributing sOccket in developing nations. In addition, profits will be used to distribute the balls at little or no cost in developing countries through organizations like Whizz Kids United.


 What was the triggering factor of this project?

This project has been made possible because in Africa more and more people use LED lamps. 

What is the business model of this project?

The busniss model is the soccket ball. You can find all the information you need above on this amazigly good website





darriussimps017@gmail.com,,+260971403393,,http://springwise.com/non-profit_social_cause/soccket/ http://www.soccket.com/

Saturday, September 14, 2019

                                           WORLD CHALLENGES 




The world is facing multiple health challenges. These range from outbreaks of vaccine-preventable diseases like measles and diphtheria, increasing reports of drug-resistant pathogens, growing rates of obesity and physical inactivity to the health impacts of environmental pollution and climate change and multiple humanitarian crises. To address these and other threats, 2019 sees the start of the World Health Organization’s new 5-year strategic plan – the 13th General Programme of Work. This plan focuses on a triple billion target: ensuring 1 billion more people benefit from access to universal health coverage, 1 billion more people are protected from health emergencies and 1 billion more people enjoy better health and well-being. Reaching this goal will require addressing the threats to health from a variety of angles.Here are 10 of the many issues that will demand attention from WHO and health partners in 2019.

                     Air pollution and climate change 



 people breathe polluted air every day. In 2019, air pollution is considered by WHO as the greatest environmental risk to health. Microscopic pollutants in the air can penetrate respiratory and circulatory systems, damaging the lungs, heart and brain, killing 7 million people prematurely every year from diseases such as cancer, stroke, heart and lung disease. Around 90% of these deaths are in low- and middle-income countries, with high volumes of emissions from industry, transport and agriculture, as well as dirty cookstoves and fuels in homes. The primary cause of air pollution (burning fossil fuels) is also a major contributor to climate change , which impacts people’s health in different ways. Between 2030 and 2050, climate change is expected to cause 250 000 additional deaths per year, from malnutrition, malaria, diarrhoea and heat stress. In October 2018, WHO held its first ever Global Conference on Air Pollution and Health in Geneva. Countries and organizations made more than 70 commitments to improve air quality. This year, the United Nations Climate Summit in September will aim to strengthen climate action and ambition worldwide. Even if all the commitments made by countries for the Paris Agreement are achieved, the world is still on a course to warm by more than 3°C this century.


                       Noncommunicable diseases 



 Noncommunicable diseases, such as diabetes, cancer and heart disease, are collectively responsible for over 70% of all deaths worldwide, or 41 million people. This includes 15 million people dying prematurely, aged between 30 and 69. Over 85% of these premature deaths are in low- and middle-income countries. The rise of these diseases has been driven by five major risk factors: tobacco use, physical inactivity, the harmful use of alcohol, unhealthy diets and air pollution. These risk factors also exacerbate mental health issues, that may originate from an early age: half of all mental illness begins by the age of 14, but most cases go undetected and untreated – suicide is the second leading cause of death among 15-19 year-olds. Among many things, this year WHO will work with governments to help them meet the global target of reducing physical inactivity by 15% by 2030 – through such actions as implementing the ACTIVE policy toolkit to help get more people being active every day.

                             Global influenza pandemic 


The world will face another influenza pandemic – the only thing we don’t know is when it will hit and how severe it will be. Global defences are only as effective as the weakest link in any country’s health emergency preparedness and response system. WHO is constantly monitoring the circulation of influenza viruses to detect potential pandemic strains: 153 institutions in 114 countries are involved in global surveillance and response . Every year, WHO recommends which strains should be included in the flu vaccine to protect people from seasonal flu. In the event that a new flu strain develops pandemic potential, WHO has set up a unique partnership with all the major players to ensure effective and equitable access to diagnostics, vaccines and antivirals (treatments), especially in developing countries.


                            Fragile and vulnerable settings



 More than 1.6 billion people (22% of the global population) live in places where protracted crises (through a combination of challenges such as drought, famine, conflict, and population displacement) and weak health services leave them without access to basic care. Fragile settings exist in almost all regions of the world, and these are where half of the key targets in the sustainable development goals, including on child and maternal health, remains unmet. WHO will continue to work in these countries to strengthen health systems so that they are better prepared to detect and respond to outbreaks, as well as able to deliver high quality health services, including immunization.


                          Antimicrobial resistance



The development of antibiotics, antivirals and antimalarials are some of modern medicine’s greatest successes. Now, time with these drugs is running out. Antimicrobial resistance – the ability of bacteria, parasites, viruses and fungi to resist these medicines – threatens to send us back to a time when we were unable to easily treat infections such as pneumonia, tuberculosis, gonorrhoea, and salmonellosis. The inability to prevent infections could seriously compromise surgery and procedures such as chemotherapy. Resistance to tuberculosis drugs is a formidable obstacle to fighting a disease that causes around 10 million people to fall ill, and 1.6 million to die, every year. In 2017, around 600 000 cases of tuberculosis were resistant to rifampicin – the most effective first-line drug – and 82% of these people had multidrug-resistant tuberculosis. Drug resistance is driven by the overuse of antimicrobials in people, but also in animals, especially those used for food production, as well as in the environment. WHO is working with these sectors to implement a global action plan to tackle antimicrobial resistance by increasing awareness and knowledge, reducing infection, and encouraging prudent use of antimicrobials.


               Ebola and other high-threat                       
                                                  

 the Democratic Republic of the Congo saw two separate Ebola outbreaks, both of which spread to cities of more than 1 million people. One of the affected provinces is also in an active conflict zone. This shows that the context in which an epidemic of a high-threat pathogen like Ebola erupts is critical – what happened in rural outbreaks in the past doesn’t always apply to densely populated urban areas or conflict-affected areas. At a conference on Preparedness for Public Health Emergencies held last December, participants from the public health, animal health, transport and tourism sectors focussed on the growing challenges of tackling outbreaks and health emergencies in urban areas . They called for WHO and partners to designate 2019 as a “Year of action on preparedness for health emergencies”. WHO’s R&D Blueprint identifies diseases and pathogens that have potential to cause a public health emergency but lack effective treatments and vaccines. This watchlist for priority research and development includes Ebola, several other haemorrhagic fevers, Zika, Nipah, Middle East respiratory syndrome coronavirus (MERS-CoV) and Severe Acute Respiratory Syndrome (SARS) and disease X, which represents the need to prepare for an unknown pathogen that could cause a serious epidemic. 


                       Weak primary health care 




Primary health care is usually the first point of contact people have with their health care system, and ideally should provide comprehensive, affordable, community-based care throughout life. Primary health care can meet the majority of a person’s health needs of the course of their life. Health systems with strong primary health care are needed to achieve universal health coverage. Yet many countries do not have adequate primary health care facilities. This neglect may be a lack of resources in low- or middle-income countries, but possibly also a focus in the past few decades on single disease programmes. In October 2018, WHO co-hosted a major global conference in Astana, Kazakhstan at which all countries committed to renew the commitment to primary health care made in the Alma-Ata declaration in 1978. In 2019, WHO will work with partners to revitalize and strengthen primary health care in countries, and follow up on specific commitments made by in the Astana Declaration.


                         Vaccine hesitancy 




 Vaccine hesitancy – the reluctance or refusal to vaccinate despite the availability of vaccines – threatens to reverse progress made in tackling vaccine-preventable diseases. Vaccination is one of the most cost-effective ways of avoiding disease – it currently prevents 2-3 million deaths a year, and a further 1.5 million could be avoided if global coverage of vaccinations improved. Measles, for example, has seen a 30% increase in cases globally. The reasons for this rise are complex, and not all of these cases are due to vaccine hesitancy. However, some countries that were close to eliminating the disease have seen a resurgence. The reasons why people choose not to vaccinate are complex; a vaccines advisory group to WHO identified complacency, inconvenience in accessing vaccines, and lack of confidence are key reasons underlying hesitancy. Health workers, especially those in communities, remain the most trusted advisor and influencer of vaccination decisions, and they must be supported to provide trusted, credible information on vaccines. In 2019, WHO will ramp up work to eliminate cervical cancer worldwide by increasing coverage of the HPV vaccine, among other interventions. 2019 may also be the year when transmission of wild poliovirus is stopped in Afghanistan and Pakistan . Last year, less than 30 cases were reported in both countries. WHO and partners are committed to supporting these countries to vaccinate every last child to eradicate this crippling disease for good.

           
                                                   Dengue




 Dengue, a mosquito-borne disease that causes flu-like symptoms and can be lethal and kill up to 20% of those with severe dengue, has been a growing threat for decades. A high number of cases occur in the rainy seasons of countries such as Bangladesh and India. Now, its season in these countries is lengthening significantly (in 2018, Bangladesh saw the highest number of deaths in almost two decades), and the disease is spreading to less tropical and more temperate countries such as Nepal, that have not traditionally seen the disease. An estimated 40% of the world is at risk of dengue fever, and there are around 390 million infections a year. WHO’s Dengue control strategy aims to reduce deaths by 50% by 2020.



                                           HIV 





The progress made against HIV has been enormous in terms of getting people tested, providing them with antiretrovirals (22 million are on treatment), and providing access to preventive measures such as a pre-exposure prophylaxis (PrEP, which is when people at risk of HIV take antiretrovirals to prevent infection). However, the epidemic continues to rage with nearly a million people every year dying of HIV/AIDS. Since the beginning of the epidemic, more than 70 million people have acquired the infection, and about 35 million people have died. Today, around 37 million worldwide live with HIV. Reaching people like sex workers, people in prison, men who have sex with men, or transgender people is hugely challenging. Often these groups are excluded from health services. A group increasingly affected by HIV are young girls and women (aged 15–24), who are particularly at high risk and account for 1 in 4 HIV infections in sub-Saharan Africa despite being only 10% of the population. This year, WHO will work with countries to support the introduction of self-testing so that more people living with HIV know their status and can receive treatment (or preventive measures in the case of a negative test result). One activity will be to act on new guidance announced In December 2018, by WHO and the International Labour Organization to support companies and organizations to offer HIV self-tests in the workplace.

Darriussimpende@gmail.com,+260971403393

Sunday, September 8, 2019

                               Moduretic 5-50 

What is Moduretic 5-50? 
    Hydrochlorothiazide is a thiazide diuretic (water pill) that helps prevent your body from absorbing too much salt, which can cause fluid retention . Amiloride is a potassium sparing-diuretic that also prevents your body from absorbing too much salt and keeps your potassium levels from getting too low. The combination of hydrochlorothiazide and amiloride is used to treat fluid retention ( edema) and high blood pressure (hypertension). Moduretic 5-50 may also be used for purposes not listed in this medication guide.

  Important Information
You should not use Moduretic 5-50 if you have kidney disease, urination problems, diabetes, or high levels of potassium in your blood. Some medicines can cause unwanted or dangerous effects when used with Moduretic 5-50. Your doctor may need to change your treatment plan if you use potassium supplements or certain diuretics ( spironolactone, triamterene).Before taking this medicine You should not use this medication if you are allergic to hydrochlorothiazide or amiloride, or if you have: kidney disease or are unable to urinate; high potassium levels ( hyperkalemia ); or if you are taking potassium supplements.to make sure Moduretic 5-50 safe for you, tell your doctor if you have: high cholesterol, heart disease, coronary artery disease ; cirrhosis or other liver disease ; glaucoma; a breathing disorder; gout; or an allergy to sulfa drugs or penicillin. This medication is not expected to be harmful to an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment. Hydrochlorothiazide can pass into breast milk and may harm a nursing baby. You should not breast-feed while you are using hydrochlorothiazide and amiloride.
  How should i take moduretic 5-50?
Follow all directions on your prescription label. Do not take Moduretic 5-50 in larger or smaller amounts or for longer than recommended. Take Moduretic 5-50 with food. Your blood pressure will need to be checked often. Your blood and urine may also be tested if you have been vomiting or are dehydrated. If you need surgery or medical tests, tell the doctor ahead of time that you are taking medication that contains hydrochlorothiazide. You may need to stop using the medicine for a short time. If you are being treated for high blood pressure, keep using this medication even if you feel well. High blood pressure often has no symptoms. You may need to use blood pressure medication for the rest of your life. Store at room temperature away from moisture, heat, and light. Do not freeze.
     What happens if I miss a dose?
Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.
         What happens if I overdose?
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. What should I avoid while taking Moduretic 5-50? Drinking alcohol can increase certain side effects of hydrochlorothiazide and amiloride. Do not use salt substitutes or low-sodium milk products that contain potassium. These products could cause your potassium levels to get too high while you are taking Moduretic 5-50. Avoid a diet high in salt. Too much salt will cause your body to retain water and can make this medication less effective. This medication may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert. Avoid becoming overheated or dehydrated during exercise and in hot weather. Follow your doctor's instructions about the type and amount of liquids you should drink. In some cases, drinking too much liquid can be as unsafe as not drinking enough.
      
            Side Effects 
 Generic Name: amiloride / hydrochlorothiazide Medically reviewed by Drugs.com. Last updated on Jan 12, 2019. 

 This document contains side effect information about amiloride / hydrochlorothiazide. Some of the dosage forms listed on this page may not apply to the brand name Moduretic 5-50. For the Consumer Applies to amiloride / hydrochlorothiazide: oral tablet Warning Oral route (Tablet) May cause hyperkalemia, which is potentially fatal if uncorrected. The risk is higher in patients with renal impairment or diabetes mellitus. Along with its needed effects, amiloride / hydrochlorothiazide may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur while taking amiloride / hydrochlorothiazide:
 More Common 

  • Abdominal pain 
  • confusion 
  • difficulty breathing
  •  irregular heartbeats 
  • nausea or vomiting
  •  nervousness numbness or tingling in the hands, feet, or lips shortness of breath weakness or heaviness of the legs
  •  Less Common 
  • Dizziness 
  • fainting fast or slow heartbeat 
  • labored breathing tightness in the chest 
  • wheezing Rare Ankle, knee, or great toe 
  • joint pain arm, back, or jaw pain blistering, peeling, or loosening of the skin 
  • bloody or black, tarry stools 
  • bloody urine 
  • burning while urinating 
  • burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
  •  chest pain, discomfort, or heaviness chills 
  • cloudy urine 
  • cold sweats coma
  •  constipation 
  • convulsions 
  • cough
  • cracks in the skin
  • decreased awareness or responsiveness 
  • decreased frequency or amount of urine 
  • diarrhea difficult or painful urination 
  • dizziness, faintness, or lightheadedness when getting up from a lying or sitting position
  •  suddenly dry mouth
  •  fever
  •  headache
  •  increase in heart rate 
  • increased blood pressure
  •  increased thirst 
  • itching
  •  joint pain, stiffness, or swelling 
  • lightheadedness 
  • loss of appetite
  •  loss of heat from the body
  •  lower back or side pain
  •  muscle pain or cramps pounding
  •  heartbeat or pulse
  •  rapid breathing
  •  red skin lesions, often with a purple center red, irritated eyes red, swollen skin
  •  scaly skin
  •  severe sleepiness 
  • severe stomach pain 
  • sore throat sores, ulcers, or white spots in the mouth or on the lips 
  • sunken eyes sweating swelling of the face, ankles, hands, fingers, or lower legs troubled breathing 
  • unusual tiredness or weakness 
vomiting of blood or material that looks like coffee grounds
 weight gain wrinkled skin.
 Get emergency help immediately if any of the following symptoms of overdose occur while taking amiloride / hydrochlorothiazide: Symptoms of Overdose Drowsiness irritability mood changes pain or weakness in the hands or feet trembling weak pulse Some side effects of amiloride / hydrochlorothiazide may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them: More Common Rash weight loss Less Common Leg ache stomach pain Rare Bad taste bloated, full feeling blurred or loss of vision changes in appetite decreased interest in sexual intercourse discouragement disturbed color perception double vision excess air or gas in the stomach or intestines feeling of constant movement of self or surroundings feeling of warmth feeling sad or empty general feeling of discomfort or illness hair loss or thinning of hair hiccups inability to have or keep an erection increased sweating increased urge to urinate during the night indigestion loss in sexual ability, desire, drive, or performance loss of bladder control loss of interest or pleasure muscle spasm night blindness overbright appearance of lights passing of gas redness of the face, neck, arms, and occasionally upper chest seeing halos around lights sensation of spinning sleepiness sleeplessness stomach fullness or discomfort stuffy nose swelling of the breasts or breast soreness in both females and males trouble concentrating trouble sleeping tunnel vision unable to sleep waking to urinate at night.

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