What is Moduretic 5-50?
Hydrochlorothiazide is a thiazide diuretic (water pill) that helps prevent your body from absorbing too much salt, which can cause fluid retention . Amiloride is a potassium sparing-diuretic that also prevents your body from absorbing too much salt and keeps your potassium levels from getting too low. The combination of hydrochlorothiazide and amiloride is used to treat fluid retention ( edema) and high blood pressure (hypertension). Moduretic 5-50 may also be used for purposes not listed in this medication guide.
You should not use Moduretic 5-50 if you have kidney disease, urination problems, diabetes, or high levels of potassium in your blood. Some medicines can cause unwanted or dangerous effects when used with Moduretic 5-50. Your doctor may need to change your treatment plan if you use potassium supplements or certain diuretics ( spironolactone, triamterene).Before taking this medicine You should not use this medication if you are allergic to hydrochlorothiazide or amiloride, or if you have: kidney disease or are unable to urinate; high potassium levels ( hyperkalemia ); or if you are taking potassium supplements.to make sure Moduretic 5-50 safe for you, tell your doctor if you have: high cholesterol, heart disease, coronary artery disease ; cirrhosis or other liver disease ; glaucoma; a breathing disorder; gout; or an allergy to sulfa drugs or penicillin. This medication is not expected to be harmful to an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment. Hydrochlorothiazide can pass into breast milk and may harm a nursing baby. You should not breast-feed while you are using hydrochlorothiazide and amiloride.
Follow all directions on your prescription label. Do not take Moduretic 5-50 in larger or smaller amounts or for longer than recommended. Take Moduretic 5-50 with food. Your blood pressure will need to be checked often. Your blood and urine may also be tested if you have been vomiting or are dehydrated. If you need surgery or medical tests, tell the doctor ahead of time that you are taking medication that contains hydrochlorothiazide. You may need to stop using the medicine for a short time. If you are being treated for high blood pressure, keep using this medication even if you feel well. High blood pressure often has no symptoms. You may need to use blood pressure medication for the rest of your life. Store at room temperature away from moisture, heat, and light. Do not freeze.
What happens if I miss a dose?
Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.
What happens if I overdose?
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. What should I avoid while taking Moduretic 5-50? Drinking alcohol can increase certain side effects of hydrochlorothiazide and amiloride. Do not use salt substitutes or low-sodium milk products that contain potassium. These products could cause your potassium levels to get too high while you are taking Moduretic 5-50. Avoid a diet high in salt. Too much salt will cause your body to retain water and can make this medication less effective. This medication may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert. Avoid becoming overheated or dehydrated during exercise and in hot weather. Follow your doctor's instructions about the type and amount of liquids you should drink. In some cases, drinking too much liquid can be as unsafe as not drinking enough.
Side Effects
Generic Name: amiloride / hydrochlorothiazide Medically reviewed by Drugs.com. Last updated on Jan 12, 2019.
This document contains side effect information about amiloride / hydrochlorothiazide. Some of the dosage forms listed on this page may not apply to the brand name Moduretic 5-50. For the Consumer Applies to amiloride / hydrochlorothiazide: oral tablet Warning Oral route (Tablet) May cause hyperkalemia, which is potentially fatal if uncorrected. The risk is higher in patients with renal impairment or diabetes mellitus. Along with its needed effects, amiloride / hydrochlorothiazide may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur while taking amiloride / hydrochlorothiazide:
More Common
- Abdominal pain
- confusion
- difficulty breathing
- irregular heartbeats
- nausea or vomiting
- nervousness numbness or tingling in the hands, feet, or lips shortness of breath weakness or heaviness of the legs
- Less Common
- Dizziness
- fainting fast or slow heartbeat
- labored breathing tightness in the chest
- wheezing Rare Ankle, knee, or great toe
- joint pain arm, back, or jaw pain blistering, peeling, or loosening of the skin
- bloody or black, tarry stools
- bloody urine
- burning while urinating
- burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
- chest pain, discomfort, or heaviness chills
- cloudy urine
- cold sweats coma
- constipation
- convulsions
- cough
- cracks in the skin
- decreased awareness or responsiveness
- decreased frequency or amount of urine
- diarrhea difficult or painful urination
- dizziness, faintness, or lightheadedness when getting up from a lying or sitting position
- suddenly dry mouth
- fever
- headache
- increase in heart rate
- increased blood pressure
- increased thirst
- itching
- joint pain, stiffness, or swelling
- lightheadedness
- loss of appetite
- loss of heat from the body
- lower back or side pain
- muscle pain or cramps pounding
- heartbeat or pulse
- rapid breathing
- red skin lesions, often with a purple center red, irritated eyes red, swollen skin
- scaly skin
- severe sleepiness
- severe stomach pain
- sore throat sores, ulcers, or white spots in the mouth or on the lips
- sunken eyes sweating swelling of the face, ankles, hands, fingers, or lower legs troubled breathing
- unusual tiredness or weakness
weight gain wrinkled skin.
Get emergency help immediately if any of the following symptoms of overdose occur while taking amiloride / hydrochlorothiazide: Symptoms of Overdose Drowsiness irritability mood changes pain or weakness in the hands or feet trembling weak pulse Some side effects of amiloride / hydrochlorothiazide may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them: More Common Rash weight loss Less Common Leg ache stomach pain Rare Bad taste bloated, full feeling blurred or loss of vision changes in appetite decreased interest in sexual intercourse discouragement disturbed color perception double vision excess air or gas in the stomach or intestines feeling of constant movement of self or surroundings feeling of warmth feeling sad or empty general feeling of discomfort or illness hair loss or thinning of hair hiccups inability to have or keep an erection increased sweating increased urge to urinate during the night indigestion loss in sexual ability, desire, drive, or performance loss of bladder control loss of interest or pleasure muscle spasm night blindness overbright appearance of lights passing of gas redness of the face, neck, arms, and occasionally upper chest seeing halos around lights sensation of spinning sleepiness sleeplessness stomach fullness or discomfort stuffy nose swelling of the breasts or breast soreness in both females and males trouble concentrating trouble sleeping tunnel vision unable to sleep waking to urinate at night.
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